MEDICAL MARIJUANA

By Dr. David Bearman (California)

11-27-2013

MEDICAL MARIJUANA:

SCIENTIFIC MECHANISMS AND CLINICAL INDICATIONS

David Bearman, MD

ABSTRACT

Finally in the early 21st century, medicinal cannabis is being rediscovered by physicians

and patients alike. This paper discusses the current state of medicinal marijuana in the U.S. We’ll

look at contemporary medicinal use in the context of the 5000-year history of the therapeutic use

of cannabis. This includes cannabis use in ancient times, in patent medicines, its use in the early

20th century, and assess the modern medicinal cannabis research that started in 1949. The

paper will cover the current legal status of medicinal cannabis, recent research, the role of the

FDA, physician practice standards, medical indications, and mechanisms of action.

INTRODUCTION

We stand at the dawn of a new era for medicinal cannabis. Since 1964, when Dr.

Raphael Mechulam, of Jerusalem University, isolated tetrahydrocannabinol (THC) we have

learned more about the marvels of the brain’s neurochemistry. There has developed a greater

understanding of the role of serotonin in depression and we have had the discovery of

endorphins, the naturally-occurring opiates, and the endocannabinoid system. In 1992, Professor

Mechulam described the endocannabinoid system. He characterized the endogenous

cannabinoid receptors and the endogenous cannabinoids that bind to these receptors.

We have crossed the threshold into exciting cannabis-related treatments for many

conditions and symptoms. Cannabis gives relief from chronic pain which arises from a myriad of

pain-producing illnesses; cannabis provides both analgesia and anti-inflammatory relief for

autoimmune diseases such as rheumatoid arthritis, fibromyalgia, complex sympathetic dystrophy,

and restless leg syndrome; and assists many with mental health problems, including attention

deficit disorder (ADD), post-traumatic stress disorder (PTSD), depression, and obsessive

compulsive disorder (OCD) – to name but a few conditions which have been shown to benefit

from cannabis and cannabinods.

© This article is copyrighted by Medical Cannabis Journal 11-27-2013

Medical Cannabis marijuana Dr Bearman endocannabinoid  

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Steven Katz
Posts: 7
Comment
help with effexor xr withdrawal for bipolar disorder and tbi
Reply #7 on : Sun November 09, 2014, 17:01:32
I live in San Diego, California. I'm a 100% disabled Navy Veteran. I'm trying to get off of antidepressant medication which I've taken for 23 years.
I'm trying to fund the right strain that causes the least memory impairment and best antidepressant effect. I went cold turkey off of 37.5mg effexor xr. It was causing me severe anxiety attacks and insomnia. I was also exposed to and invested via the water supply multiple toxic chemicals. I am now or always have been sensitive to drugs and chemicals.
I have a very low tolerance for marijuana and if I accidentally inhale too much I get very ill, sick, dizzy and vimit. I got my psychiatrist to write me a letter to get a medical marijuana licence and have been unable to bring it to health and human services because I'm unable To drive mostly because of the terrible effexor xr withdrawal. So I'm trying to find the correct strain and dose for myself.
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Tattoo299
Reply #6 on : Tue October 28, 2014, 14:21:01
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Tony Heardp
Posts: 7
Comment
Medical marijuana
Reply #5 on : Tue August 05, 2014, 10:36:37
I agree for it to be used for medical reasons. I suffer from chronic pain due to failed back operation. I take 120mg of morphine twice a day + 20mg of codine and other tablets to have some quality of life.the side affects are a pain in itself. I'd rather smoke marijuana and stop taking morphine,I think smoking marijuana would be fare better than taking morphine but where do I get it? I'm looking for help,can you help me? Are there any medical testing going on?if there are please tell me or get them to get in touch with me.The pain management at the flinders pain management unit can't help me any more,I can't even have injections any more because they can't get the needle in there any more,and my injury is dejenartive +I have bursitis and suffer from chronic ostio arthritis.
Maxim
Posts: 7
Comment
I am extremely ispri
Reply #4 on : Thu July 31, 2014, 08:26:51
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Misty Richard
Posts: 7
Comment
dysautonomia and medicinal marijuana
Reply #3 on : Sat March 29, 2014, 06:59:44
Medicinal marijuana is considered a treatment option for dysautonomia. I have severe autonkic system failure which includes my heart, kidneys etc. I use cannabis for the pain and it helps in numerous ways. It relaxed my heartbeat, rekeves pain, stops the restless limb syndrome etc.

Smoking marijuana raises blood pressure so it is good for people with pots where their blood pressure is low. Stay away from the sativas and look more for the indica strains. Look up dysautonomia and studies being done by mayo clinic. Good luck.
Bobbie Scott
Posts: 7
Comment
medical marijuana for treatment of dysautonomia
Reply #2 on : Thu January 16, 2014, 20:10:21
I have a friend whose daughter (in mid thirties) has dysautonomia. She is currently in the hospital for treatment of pain and has been there for over a month. She was and is essentially bedbound and tube fed but very much alert and cognitively aware. Do you know if there has been any use of medical marijuana for treatment of dysautonomia?
Ted
Posts: 7
Comment
An abstract of an article by Dr. Bearman
Reply #1 on : Tue December 03, 2013, 18:03:10
I agree whole heartedly with your article.I hope we have more Drs. like you.I suffer from severe lower back pain and arthritis in my neck and shoulder.The Drs. performed surgery on my back in '93 and now it's gone back to the way it was.I'm licensed in the state of Michigan to use cannabis for the pain.Thank you for the article.

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